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	<title>Comments on: Anti-oxidants: Do We Need Them?</title>
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	<link>http://yourdoctorsorders.com/2011/10/anti-oxidants-do-we-need-them/</link>
	<description>A blog by Terry Simpson, MD, FACS</description>
	<lastBuildDate>Thu, 17 May 2012 17:03:05 +0000</lastBuildDate>
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		<title>By: The Doc</title>
		<link>http://yourdoctorsorders.com/2011/10/anti-oxidants-do-we-need-them/comment-page-1/#comment-9123</link>
		<dc:creator>The Doc</dc:creator>
		<pubDate>Tue, 08 May 2012 14:56:37 +0000</pubDate>
		<guid isPermaLink="false">http://skepticdoc.com/?p=72#comment-9123</guid>
		<description>Humans and guinea pigs lack the enzyme that converts L-gulonolactone to 2-keto-L-gulonolactone which is required for the biosynthesis of ascorbic acid, L-ascorbic acid, and L-dehydroascorbic acid which are all equivalent because of the reduction of the dehydroascorbate to ascorbate in the body. It turns out that the enolic hydroxyl groups dissaociate in normal physiologic range and is one of the strongest naturally occurring&lt;strong&gt; REDUCING &lt;/strong&gt;agents known.  But let us be very clear the in vivo (in people) role of ascorbate as a reductant in non enzymatic reactions is &lt;strong&gt;not&lt;/strong&gt; established. Hence the role of ascorbic acid in a test tube is far from its biologic or in vivo activity. Scurvy comes from inadequate or abnormal collagen synthesis, which happens when you do not have the ascorbate to enhance the prolyl and lysyl hydroxylase activities - resulting in poorly formed collagen and the skin lesions, bone fractures, and etc.  Vitamin C is  an antioxidant , but it is called a vitamin because humans cannot make it and we depend on ascorbate to act as a reductant in certain cellular/biochemical pathways. Nor or are vitamins called vitamins because they are anti-oxidants. Oxidation is a necessary and useful process for the body to survive and if we were to be able to &quot;overwhelm&quot; the system with anti-oxidants we would die within minutes or be overwhelmed with sepsis from bacteria.  We do need vitamins- and  oxidation and reduction pathways are our basic biochemical reactions- they, however, are not what the health wizards like Dr. Oz are talking about - if indeed they even understand what they are talking about.The best way to deal with false information is to give real information and facts. We do need vitamins, but there has not ever been a role established for supplementation with anti-oxidants.  In fact, with Vitamin C if there is too much, the reductant can harm DNA - thus, too much of Vitamin C can be harmful.  (I know Linus Pauling is turning over in his grave)</description>
		<content:encoded><![CDATA[<p>Humans and guinea pigs lack the enzyme that converts L-gulonolactone to 2-keto-L-gulonolactone which is required for the biosynthesis of ascorbic acid, L-ascorbic acid, and L-dehydroascorbic acid which are all equivalent because of the reduction of the dehydroascorbate to ascorbate in the body. It turns out that the enolic hydroxyl groups dissaociate in normal physiologic range and is one of the strongest naturally occurring<strong> REDUCING </strong>agents known.  But let us be very clear the in vivo (in people) role of ascorbate as a reductant in non enzymatic reactions is <strong>not</strong> established. Hence the role of ascorbic acid in a test tube is far from its biologic or in vivo activity. Scurvy comes from inadequate or abnormal collagen synthesis, which happens when you do not have the ascorbate to enhance the prolyl and lysyl hydroxylase activities &#8211; resulting in poorly formed collagen and the skin lesions, bone fractures, and etc.  Vitamin C is  an antioxidant , but it is called a vitamin because humans cannot make it and we depend on ascorbate to act as a reductant in certain cellular/biochemical pathways. Nor or are vitamins called vitamins because they are anti-oxidants. Oxidation is a necessary and useful process for the body to survive and if we were to be able to &#8220;overwhelm&#8221; the system with anti-oxidants we would die within minutes or be overwhelmed with sepsis from bacteria.  We do need vitamins- and  oxidation and reduction pathways are our basic biochemical reactions- they, however, are not what the health wizards like Dr. Oz are talking about &#8211; if indeed they even understand what they are talking about.The best way to deal with false information is to give real information and facts. We do need vitamins, but there has not ever been a role established for supplementation with anti-oxidants.  In fact, with Vitamin C if there is too much, the reductant can harm DNA &#8211; thus, too much of Vitamin C can be harmful.  (I know Linus Pauling is turning over in his grave)</p>
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		<title>By: Adam C.</title>
		<link>http://yourdoctorsorders.com/2011/10/anti-oxidants-do-we-need-them/comment-page-1/#comment-9121</link>
		<dc:creator>Adam C.</dc:creator>
		<pubDate>Tue, 08 May 2012 00:30:07 +0000</pubDate>
		<guid isPermaLink="false">http://skepticdoc.com/?p=72#comment-9121</guid>
		<description>While you make fair points in the main, several vitamins are called &quot;anti-oxidants&quot; , and are by definition vitamins are things we need our body can&#039;t produce itself.  So...  yeah, I&#039;m afraid that this isn&#039;t really accurate; and I don&#039;t think the best way to deal with false information is alternate incorrect information; better to deal with the facts - we need Vitamins, but do not more than the RDA unless your doctor says you do.</description>
		<content:encoded><![CDATA[<p>While you make fair points in the main, several vitamins are called &#8220;anti-oxidants&#8221; , and are by definition vitamins are things we need our body can&#8217;t produce itself.  So&#8230;  yeah, I&#8217;m afraid that this isn&#8217;t really accurate; and I don&#8217;t think the best way to deal with false information is alternate incorrect information; better to deal with the facts &#8211; we need Vitamins, but do not more than the RDA unless your doctor says you do.</p>
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		<title>By: The Doc</title>
		<link>http://yourdoctorsorders.com/2011/10/anti-oxidants-do-we-need-them/comment-page-1/#comment-8996</link>
		<dc:creator>The Doc</dc:creator>
		<pubDate>Mon, 20 Feb 2012 18:59:14 +0000</pubDate>
		<guid isPermaLink="false">http://skepticdoc.com/?p=72#comment-8996</guid>
		<description>Your body is a great buffer system- and the stomach has a very low pH. So it won&#039;t bother it</description>
		<content:encoded><![CDATA[<p>Your body is a great buffer system- and the stomach has a very low pH. So it won&#8217;t bother it</p>
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		<title>By: Henry K</title>
		<link>http://yourdoctorsorders.com/2011/10/anti-oxidants-do-we-need-them/comment-page-1/#comment-8988</link>
		<dc:creator>Henry K</dc:creator>
		<pubDate>Fri, 17 Feb 2012 09:27:36 +0000</pubDate>
		<guid isPermaLink="false">http://skepticdoc.com/?p=72#comment-8988</guid>
		<description>How do you feel about ph levels? example: the average can of soda has a really low ph level of 2-3 ph.... Is this really bad for your body? Will this significantly effect your appearance and health overtime?</description>
		<content:encoded><![CDATA[<p>How do you feel about ph levels? example: the average can of soda has a really low ph level of 2-3 ph&#8230;. Is this really bad for your body? Will this significantly effect your appearance and health overtime?</p>
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		<title>By: Susanna Minkins</title>
		<link>http://yourdoctorsorders.com/2011/10/anti-oxidants-do-we-need-them/comment-page-1/#comment-8255</link>
		<dc:creator>Susanna Minkins</dc:creator>
		<pubDate>Sat, 08 Oct 2011 07:36:58 +0000</pubDate>
		<guid isPermaLink="false">http://skepticdoc.com/?p=72#comment-8255</guid>
		<description>Definitely consider that which you stated. Your favourite reason appeared to be on the internet the simplest thing to take note of. I say to you, I definitely get annoyed at the same time as people think about issues that they just don&#039;t realize about. You managed to hit the nail upon the top and outlined out the whole thing without having side effect , folks could take a signal. Will likely be again to get more. Thank you</description>
		<content:encoded><![CDATA[<p>Definitely consider that which you stated. Your favourite reason appeared to be on the internet the simplest thing to take note of. I say to you, I definitely get annoyed at the same time as people think about issues that they just don&#8217;t realize about. You managed to hit the nail upon the top and outlined out the whole thing without having side effect , folks could take a signal. Will likely be again to get more. Thank you</p>
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		<title>By: Tinkr.net &#187; Tinkr Lnks for 5/30/09</title>
		<link>http://yourdoctorsorders.com/2011/10/anti-oxidants-do-we-need-them/comment-page-1/#comment-14</link>
		<dc:creator>Tinkr.net &#187; Tinkr Lnks for 5/30/09</dc:creator>
		<pubDate>Sun, 31 May 2009 10:17:15 +0000</pubDate>
		<guid isPermaLink="false">http://skepticdoc.com/?p=72#comment-14</guid>
		<description>[...] Anti oxidants - do we need them [...]</description>
		<content:encoded><![CDATA[<p>[...] Anti oxidants &#8211; do we need them [...]</p>
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